Beginning her career as a model, Rao made her acting debut with Ab Ke Baras (2002), which went unnoticed. However, she grew into prominence when she starred in Ken Ghosh's love-story, Ishq Vishk (2003) and earned her first Filmfare nomination in the Best Female Debut category. Delivering acclaimed performances and commercial success with films like Main Hoon Na (2004) and Vivah (2006), her biggest commercial success so far, she has established herself as one of the most promising actresses of Bollywood.
